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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM391314 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biochemical HTRF Assay | ||
| IC50 | 0.030±n/a nM | ||
| Citation |  Childers, ML; Fuller, P; Guerin, D; Katz, JD; Pu, Q; Scott, ME; Thompson, CF; Martinez, M; Falcone, D; Torres, L; Deng, Y; Kurukulasuriya, R; Zeng, H; Bai, Y; Kong, N; Liu, Y; Zheng, Z Geminally substituted cyanoethylpyrazolo pyridones as Janus kinase inhibitors US Patent US9957264 Publication Date 5/1/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
| ||
| BDBM391314 | |||
| n/a | |||
| Name | BDBM391314 | ||
| Synonyms: | Trans 2-(1-(3-((4- chlorophenyl)amino)-4-oxo- 4,5-dihydro-1H-pyrazolo[4,3- c]pyridin-1-yl)-4-(3- methoxyazetidin-1- yl)cyclohexyl)acetonitrile | US9957264, Example 18-8 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H27ClN6O2 | ||
| Mol. Mass. | 466.963 | ||
| SMILES | COC1CN(C1)[C@H]1CC[C@@](CC#N)(CC1)n1nc(Nc2ccc(Cl)cc2)c2c1cc[nH]c2=O |r,wU:9.16,wD:6.6,(4.93,8.57,;3.44,8.17,;3.04,6.68,;3.81,5.35,;2.48,4.58,;1.71,5.91,;2.08,3.09,;.59,2.69,;.2,1.2,;1.28,.12,;.02,-.77,;.16,-2.3,;.29,-3.84,;2.77,.51,;3.17,2,;-.2,-.28,;-.83,-1.69,;-2.36,-1.53,;-3.45,-2.62,;-3.05,-4.11,;-4.14,-5.19,;-3.74,-6.68,;-2.25,-7.08,;-1.86,-8.57,;-1.17,-5.99,;-1.56,-4.5,;-2.68,-.02,;-1.35,.75,;-1.35,2.29,;-2.68,3.06,;-4.01,2.29,;-4.01,.75,;-5.35,-.02,)| | ||
| Structure | 
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