| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 |
|---|
| Ligand | BDBM391366 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical HTRF Assay |
|---|
| IC50 | 0.040±n/a nM |
|---|
| Citation |  Childers, ML; Fuller, P; Guerin, D; Katz, JD; Pu, Q; Scott, ME; Thompson, CF; Martinez, M; Falcone, D; Torres, L; Deng, Y; Kurukulasuriya, R; Zeng, H; Bai, Y; Kong, N; Liu, Y; Zheng, Z Geminally substituted cyanoethylpyrazolo pyridones as Janus kinase inhibitors US Patent US9957264 Publication Date 5/1/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase JAK2 |
|---|
| Name: | Tyrosine-protein kinase JAK2 |
|---|
| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 130684.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O60674 |
|---|
| Residue: | 1132 |
|---|
| Sequence: | MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG
EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC
YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA
MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
|
|
|
|---|
| BDBM391366 |
|---|
| n/a |
|---|
| Name | BDBM391366 |
|---|
| Synonyms: | US9957264, Example 21-2 | [(1R,2R)-1-{3-[(3,3- dimethyl-2-oxo-2,3- dihydro-1H-indol-6- yl)amino]-4-oxo-4,5- dihydro-1H-pyrazolo[4,3- c]pyridin-1-yl}-2- fluorocyclohexyl] acetonitrile (from I-19A) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H25FN6O2 |
|---|
| Mol. Mass. | 448.4927 |
|---|
| SMILES | CC1(C)C(=O)Nc2cc(Nc3nn(c4cc[nH]c(=O)c34)[C@@]3(CC#N)CCCC[C@H]3F)ccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
