| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [1-999,L858R] |
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| Ligand | BDBM391742 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Assay on In Vitro Enzyme-Inhibiting Activity |
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| IC50 | 88.0±n/a nM |
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| Citation |  Wu, F Tyrosine kinase inhibitor and uses thereof US Patent US10300058 Publication Date 5/28/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [1-999,L858R] |
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| Name: | Epidermal growth factor receptor [1-999,L858R] |
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| Synonyms: | EGFR | EGFR(L858R) | EGFR_HUMAN | ERBB | ERBB1 | HER1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 111216.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[1-999,L858R] |
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| Residue: | 999 |
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| Sequence: | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYR
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| BDBM391742 |
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| n/a |
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| Name | BDBM391742 |
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| Synonyms: | N-(3-((2-((2-methoxy-4-(1-(methylsulfonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide | US10300058, Compound 27 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29F3N6O4S |
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| Mol. Mass. | 590.617 |
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| SMILES | COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)C1CCN(CC1)S(C)(=O)=O |
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| Structure | 
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