Reaction Details |
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Target | Epidermal growth factor receptor [1-999,L858R] |
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Ligand | BDBM391743 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Assay on In Vitro Enzyme-Inhibiting Activity |
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IC50 | 11.0±n/a nM |
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Citation | Wu, F Tyrosine kinase inhibitor and uses thereof US Patent US10300058 Publication Date 5/28/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Epidermal growth factor receptor [1-999,L858R] |
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Name: | Epidermal growth factor receptor [1-999,L858R] |
Synonyms: | EGFR | EGFR(L858R) | EGFR_HUMAN | ERBB | ERBB1 | HER1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 111216.35 |
Organism: | Homo sapiens (Human) |
Description: | P00533[1-999,L858R] |
Residue: | 999 |
Sequence: | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYR
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BDBM391743 |
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n/a |
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Name | BDBM391743 |
Synonyms: | N-(3-((2-((2-methoxy-4-(4-morpholinopiperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide | US10300058, Compound 28 |
Type | Small organic molecule |
Emp. Form. | C30H34F3N7O3 |
Mol. Mass. | 597.6313 |
SMILES | COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCC(CC1)N1CCOCC1 |
Structure |
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