| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase XIAP [1-168]/[124-242] |
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| Ligand | BDBM391827 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assays |
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| Ki | >50000±n/a nM |
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| Citation |  Pache, L; Chanda, SK; Vamos, MD; Cosford, ND; Teriete, P; Marlett, J; Diaz, A; Young, JA Use of inhibitor of apoptosis protein (IAP) antagonists in HIV therapy US Patent US10300074 Publication Date 5/28/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| E3 ubiquitin-protein ligase XIAP [1-168]/[124-242] |
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| Name: | E3 ubiquitin-protein ligase XIAP [1-168]/[124-242] |
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| Synonyms: | XIAP BIR1/2 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | E3 ubiquitin-protein ligase XIAP [1-168] |
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| Synonyms: | API3 | BIRC4 | IAP3 | XIAP | XIAP BIR1 | XIAP_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 18844.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P98170[1-168] |
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| Residue: | 168 |
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| Sequence: | MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLK
|
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| Component 2 |
| Name: | E3 ubiquitin-protein ligase XIAP [124-242] |
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| Synonyms: | API3 | BIRC4 | IAP3 | XIAP | XIAP BIR2 | XIAP_HUMAN |
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| Type: | n/a |
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| Mol. Mass.: | 13841.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P98170[124-242] |
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| Residue: | 119 |
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| Sequence: | RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRE
LASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESD
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| BDBM391827 |
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| n/a |
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| Name | BDBM391827 |
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| Synonyms: | US10300074, Compd 22 | US10300074, Compd 23 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26N4O4 |
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| Mol. Mass. | 398.4555 |
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| SMILES | CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CCC(N2C1=O)C(=O)n1ccc2ccccc12 |r| |
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| Structure | 
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