| Reaction Details |
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 | Report a problem with these data |
| Target | Mast/stem cell growth factor receptor Kit [D816V] |
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| Ligand | BDBM392375 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Exemplary c-Kit Biochemical Assay |
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| Ki | <1000±n/a nM |
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| Citation |  Wu, G; Chan, K; Ewing, T; Ibrahim, PN; Lin, J; Nespi, M; Spevak, W; Zhang, Y Compounds and methods for kinase modulation, and indications therefor US Patent US10301280 Publication Date 5/28/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mast/stem cell growth factor receptor Kit [D816V] |
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| Name: | Mast/stem cell growth factor receptor Kit [D816V] |
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| Synonyms: | KIT | KIT_HUMAN | Mast/stem cell growth factor receptor Kit (D816V) | Mast/stem cell growth factor receptor Kit 1 (D816V) | SCFR | Tyrosine-protein kinase Kit (Kit)(D816V) |
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| Type: | Protein |
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| Mol. Mass.: | 109854.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human Kit D816V mutant |
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| Residue: | 976 |
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| Sequence: | MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD
PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV
DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH
RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS
SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN
VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE
DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR
LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS
SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV
MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF
GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC
TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE
YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM
AFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPES
IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY
DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV
GSTASSSQPLLVHDDV
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| BDBM392375 |
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| n/a |
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| Name | BDBM392375 |
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| Synonyms: | 3-(cyanomethyl)-N-[2-(4- fluorophenyl)- 1H-pyrrolo[2,3-b]pyridin-5- yl]benzamide | US10301280, Compound P-2021 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H15FN4O |
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| Mol. Mass. | 370.3791 |
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| SMILES | Fc1ccc(cc1)-c1cc2cc(NC(=O)c3cccc(CC#N)c3)cnc2[nH]1 |
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| Structure | 
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