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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cytochrome P450 3A4 | ||
| Ligand | BDBM50032219 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | 3700±n/a nM | ||
| Citation |  Diaz, P; Isoherranen, N; Buttrick, B; Guilloteau, N Specific inhibitors of cytochrome P450 26 retinoic acid hydroxylase US Patent US9963439 Publication Date 5/8/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cytochrome P450 3A4 | |||
| Name: | Cytochrome P450 3A4 | ||
| Synonyms: | Albendazole monooxygenase | Albendazole sulfoxidase | CP3A4_HUMAN | CYP3A3 | CYP3A4 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 3A4 (CYP3A4) | Cytochrome P450 HLp | Nifedipine oxidase | Quinine 3-monooxygenase | Taurochenodeoxycholate 6-alpha-hydroxylase | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 57349.57 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 503 | ||
| Sequence: |
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| BDBM50032219 | |||
| n/a | |||
| Name | BDBM50032219 | ||
| Synonyms: | (E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-enyl)benzoic acid | 4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-enyl)benzoic acid | 4-[(1E)-2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)PROP-1-ENYL]BENZOIC ACID | 4-[(E)-2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid | 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid | 4-[2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid | CHEMBL275311 | US9963439, TTNPB | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H28O2 | ||
| Mol. Mass. | 348.4779 | ||
| SMILES | C\C(=C/c1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C | ||
| Structure | 
| ||