Reaction Details |
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Target | Botulinum neurotoxin type A2 [1-425] |
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Ligand | BDBM28914 |
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Substrate/Competitor | SNAP-25-based peptide substrate |
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Meas. Tech. | In Vitro Assessment of Peptide Substrate Cleavage by BoNTA-LC |
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pH | 7.4±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 21000±2500 nM |
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Citation | Moe, ST; Thompson, AB; Smith, GM; Fredenburg, RA; Stein, RL; Jacobson, AR Botulinum neurotoxin serotype A inhibitors: small-molecule mercaptoacetamide analogs. Bioorg Med Chem17:3072-9 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Botulinum neurotoxin type A2 [1-425] |
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Name: | Botulinum neurotoxin type A2 [1-425] |
Synonyms: | BXA2_CLOBJ | BoNT/A LC | Botulinum Neurotoxin Type A | Botulinum neurotoxin A light chain | atx | bna | bonT | bont/a2 | botA |
Type: | Metalloprotease |
Mol. Mass.: | 48687.43 |
Organism: | Clostridium botulinum |
Description: | Recombinant C. botulinum LC/A (1-425) was expressed in E. coli. |
Residue: | 425 |
Sequence: | MPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLN
PPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGG
STIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHDVLNLTRNGY
GSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAEHRLYGIAINPN
RVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDVASTLNKA
KSIIGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVNFFKV
INRKTYLNFDKAVFRINIVPDENYTIKDGFNLKGANLSTNFNGQNTEINSRNFTRLKNFT
GLFEF
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BDBM28914 |
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SNAP-25-based peptide substrate |
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Name: | SNAP-25-based peptide substrate |
Synonyms: | n/a |
Type: | Fluorescent peptide |
Mol. Mass.: | 3503.44 |
Organism: | n/a |
Description: | n/a |
Residue: | 29 |
Sequence: | SNRTRIDEAN[2,4-dinitrophenyl-K]RACRML
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