Reaction Details |
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Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Ligand | BDBM29026 |
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Substrate/Competitor | BDBM14700 |
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Meas. Tech. | DHODH Inhibition Assay |
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pH | 8±n/a |
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Temperature | 298.15±n/a K |
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Ki | 26000±n/a nM |
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IC50 | 223600±n/a nM |
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Km | 13400±n/a nM |
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Citation | Davies, M; Heikkilä, T; McConkey, GA; Fishwick, CW; Parsons, MR; Johnson, AP Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. J Med Chem52:2683-93 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase | PYRD_PLAF7 |
Type: | Enzyme |
Mol. Mass.: | 65581.88 |
Organism: | Plasmodium falciparum (isolate 3D7) |
Description: | Q08210 |
Residue: | 569 |
Sequence: | MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
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BDBM29026 |
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BDBM14700 |
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Name | BDBM29026 |
Synonyms: | CHEMBL142996 | cyanocyclopropylpropenamide, 11 |
Type | Small organic molecule |
Emp. Form. | C19H16N2O2 |
Mol. Mass. | 304.3425 |
SMILES | O=C(Nc1ccc(cc1)-c1ccccc1)C(C#N)C(=O)C1CC1 |
Structure |
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