| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM29029 |
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| Substrate/Competitor | BDBM14700 |
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| Meas. Tech. | DHODH Inhibition Assay |
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| pH | 8±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 1000±n/a nM |
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| IC50 | 8600±n/a nM |
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| Km | 13400±n/a nM |
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| Citation |  Davies, M; Heikkilä, T; McConkey, GA; Fishwick, CW; Parsons, MR; Johnson, AP Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. J Med Chem52:2683-93 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase | PYRD_PLAF7 |
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| Type: | Enzyme |
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| Mol. Mass.: | 65581.88 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | Q08210 |
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| Residue: | 569 |
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| Sequence: | MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
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| BDBM29029 |
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| BDBM14700 |
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| Name | BDBM29029 |
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| Synonyms: | cyanohydroxybutenamide, 19 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15ClN2O3 |
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| Mol. Mass. | 342.776 |
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| SMILES | COc1ccccc1-c1ccc(NC(=O)C(C#N)C(C)=O)c(Cl)c1 |
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| Structure | 
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