| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 3 |
|---|
| Ligand | BDBM393849 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro GIRK Thallium Flux Assay (2.5 minutes) |
|---|
| EC50 | 300±n/a nM |
|---|
| Citation |  Cosford, ND; Raveendra-Panickar, D; Sheffler, DJ Metabotropic glutamate receptor negative allosteric modulators (NAMS) and uses thereof US Patent US9969726 Publication Date 5/15/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Metabotropic glutamate receptor 3 |
|---|
| Name: | Metabotropic glutamate receptor 3 |
|---|
| Synonyms: | GRM3_RAT | Gprc1c | Grm3 | Mglur3 | glutamate receptor, metabotropic 3 precursor |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 98971.84 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P31422 |
|---|
| Residue: | 879 |
|---|
| Sequence: | MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRI
NEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV
DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD
KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC
IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVAS
DGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
CSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD
AMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSY
LKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL
VDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIK
HNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALL
TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLP
EKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI
IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLH
LNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL
|
|
|
|---|
| BDBM393849 |
|---|
| n/a |
|---|
| Name | BDBM393849 |
|---|
| Synonyms: | US10597367, Example 137 | US9969726, Example 137 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H15F3N4O3S |
|---|
| Mol. Mass. | 460.429 |
|---|
| SMILES | Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)S(=O)(=O)c1ncccn1 |c:4| |
|---|
| Structure | 
|
|---|
Search and Browse
