| Reaction Details |
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 | Report a problem with these data |
| Target | Transcription activator BRG1 [1448-1575] |
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| Ligand | BDBM394492 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | BRG1 TR-FRET Binding Assay |
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| IC50 | 18.5±n/a nM |
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| Citation |  Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Therapeutic compounds and uses thereof US Patent US10308614 Publication Date 6/4/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcription activator BRG1 [1448-1575] |
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| Name: | Transcription activator BRG1 [1448-1575] |
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| Synonyms: | ATP-dependent helicase SMARCA4 | BAF190A | BRG1 | His-BRG1 (A1448-S1575) | SMARCA4 | SMCA4_HUMAN | SNF2B | SNF2L4 | Transcription activator BRG1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 14937.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51532(A1448-S1575) |
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| Residue: | 128 |
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| Sequence: | AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDF
KKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKE
DDSEGEES
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| BDBM394492 |
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| n/a |
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| Name | BDBM394492 |
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| Synonyms: | (S)-2-(6-amino-5-(3-methyl-4-((1-methyl-1H-imidazol-2-yl)methyl)piperazin-1-yl)pyridazin-3-yl)phenol | US10308614, Example 92 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25N7O |
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| Mol. Mass. | 379.4588 |
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| SMILES | C[C@H]1CN(CCN1Cc1nccn1C)c1cc(nnc1N)-c1ccccc1O |r| |
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| Structure | 
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