| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 |
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| Ligand | BDBM395785 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | CDK Assay |
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| IC50 | <10±n/a nM |
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| Citation |  Cheng, P; Cao, W Preparation and use of kinase inhibitor US Patent US10308654 Publication Date 6/4/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 |
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| Name: | Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 |
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| Synonyms: | CDK4/CyclinD1 | cdk4 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| Component 2 |
| Name: | G1/S-specific cyclin-D1 |
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| Synonyms: | CCND1_MOUSE | Ccnd1 | Cyclin D1 | Cyl-1 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33418.84 |
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| Organism: | Mus musculus (mouse) |
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| Description: | n/a |
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| Residue: | 295 |
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| Sequence: | MEHQLLCCEVETIRRAYPDTNLLNDRVLRAMLKTEETCAPSVSYFKCVQKEIVPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPLKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEADENKQTIRK
HAQTFVALCATDVKFISNPPSMVAAGSVVAAMQGLNLGSPNNFLSCYRTTHFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNVDPKATEEEGEVEEEAGLACTPTDVRDVDI
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| BDBM395785 |
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| n/a |
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| Name | BDBM395785 |
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| Synonyms: | US10308654, Example 13 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H31N9O |
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| Mol. Mass. | 449.5519 |
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| SMILES | CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1N1CCCCC1 |
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| Structure | 
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