| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ghrelin O-acyltransferase |
|---|
| Ligand | BDBM396192 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | hGOAT Activity in HEK293 Cells after Incubation |
|---|
| IC50 | 0.082±n/a nM |
|---|
| Citation |  Godbout, C; Trieselmann, T; Vintonyak, V Oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors US Patent US10308667 Publication Date 6/4/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ghrelin O-acyltransferase |
|---|
| Name: | Ghrelin O-acyltransferase |
|---|
| Synonyms: | GOAT | Ghrelin O-acyltransferase (GOAT) | MBOA4_HUMAN | MBOAT4 | Membrane-bound O-acyltransferase domain-containing protein 4 | O-acyltransferase domain-containing protein 4 | OACT4 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49733.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96T53 |
|---|
| Residue: | 435 |
|---|
| Sequence: | MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYA
VLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITL
SSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSL
CSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFEC
IYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRIS
VFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYL
IHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVY
CILLLLLAKRKHKCN
|
|
|
|---|
| BDBM396192 |
|---|
| n/a |
|---|
| Name | BDBM396192 |
|---|
| Synonyms: | 6-[5-Bromo-6-(3-methyl-oxetan-3-ylmethoxy)-pyridin-2-ylmethyl]-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridin-7-ylamine | US10308667, Example 95 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H18BrN5O3 |
|---|
| Mol. Mass. | 420.261 |
|---|
| SMILES | Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(OCC2(C)COC2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
