| Reaction Details |
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 | Report a problem with these data |
| Target | Ghrelin O-acyltransferase |
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| Ligand | BDBM396224 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | hGOAT Activity in HEK293 Cells after Incubation |
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| IC50 | 0.100±n/a nM |
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| Citation |  Godbout, C; Trieselmann, T; Vintonyak, V Oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors US Patent US10308667 Publication Date 6/4/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ghrelin O-acyltransferase |
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| Name: | Ghrelin O-acyltransferase |
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| Synonyms: | GOAT | Ghrelin O-acyltransferase (GOAT) | MBOA4_HUMAN | MBOAT4 | Membrane-bound O-acyltransferase domain-containing protein 4 | O-acyltransferase domain-containing protein 4 | OACT4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 49733.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96T53 |
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| Residue: | 435 |
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| Sequence: | MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYA
VLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITL
SSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSL
CSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFEC
IYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRIS
VFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYL
IHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVY
CILLLLLAKRKHKCN
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| BDBM396224 |
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| n/a |
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| Name | BDBM396224 |
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| Synonyms: | 3-[6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridin-6-ylmethyl)-3-bromo-pyridin-2-ylamino]-2,2-di methyl-propionitrile | US10308667, Example 127 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18BrN7O |
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| Mol. Mass. | 416.275 |
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| SMILES | Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(NCC(C)(C)C#N)n1 |
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| Structure | 
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