| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bile acid receptor |
|---|
| Ligand | BDBM21674 |
|---|
| Substrate/Competitor | biotin-tagged SRC-1 |
|---|
| Meas. Tech. | HTRF Coactivator Recruitment Assay |
|---|
| pH | 7±n/a |
|---|
| Temperature | 277.15±n/a K |
|---|
| EC50 | 8300±n/a nM |
|---|
| Citation |  Soisson, SM; Parthasarathy, G; Adams, AD; Sahoo, S; Sitlani, A; Sparrow, C; Cui, J; Becker, JW Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation. Proc Natl Acad Sci U S A105:5337-42 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
|---|
| |
| Bile acid receptor |
|---|
| Name: | Bile acid receptor |
|---|
| Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor |
|---|
| Type: | Nuclear Receptor |
|---|
| Mol. Mass.: | 55916.24 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96RI1 |
|---|
| Residue: | 486 |
|---|
| Sequence: | MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYS
NVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTK
KPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCV
MDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEG
RDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLI
LTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSD
LLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK
LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLC
EIWDVQ
|
|
|
|---|
| BDBM21674 |
|---|
| biotin-tagged SRC-1 |
|---|
| Name: | Nuclear receptor coactivator 1 (aa 568-780) |
|---|
| Synonyms: | BHLHE74 | NCOA1 | NCOA1_HUMAN | SRC1 | Steroid receptor coactivator 1 (aa 568-780) |
|---|
| Type: | Other Protein Type |
|---|
| Mol. Mass.: | 23127.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q15788 aa 568-780 |
|---|
| Residue: | 213 |
|---|
| Sequence: | NSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGKPLDSGLLHNNDRLSDGDSKYS
QTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSHSSLTERH
KILHRLLQEGSPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQ
LLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ
|
|
|
|---|
Search and Browse
