Reaction Details |
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Target | E3 ubiquitin-protein ligase Mdm2 |
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Ligand | BDBM31197 |
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Substrate/Competitor | PMDM6-F Peptide |
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Meas. Tech. | Fluorescence Polarization-Based (FP-Based) Binding Assay |
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pH | 7.5±n/a |
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Temperature | 296.15±n/a K |
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Ki | 36±9 nM |
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Citation | Ding, K; Lu, Y; Nikolovska-Coleska, Z; Wang, G; Qiu, S; Shangary, S; Gao, W; Qin, D; Stuckey, J; Krajewski, K; Roller, PP; Wang, S Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction. J Med Chem49:3432-5 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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E3 ubiquitin-protein ligase Mdm2 |
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Name: | E3 ubiquitin-protein ligase Mdm2 |
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
Type: | Oncoprotein |
Mol. Mass.: | 55196.54 |
Organism: | Homo sapiens (Human) |
Description: | Q00987 |
Residue: | 491 |
Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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BDBM31197 |
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PMDM6-F Peptide |
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Name: | PMDM6-F Peptide |
Synonyms: | n/a |
Type: | Fluorescence probe |
Mol. Mass.: | 4802.47 |
Organism: | n/a |
Description: | n/a |
Residue: | 45 |
Sequence: | 5-FAM-betaAla-betaAla-Phe-Met-Aib-pTyr-(6-Cl-L-Trp)-Glu-Ac3c
-Leu-Asn-NH2
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