Reaction Details |
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Target | Receptor-type tyrosine-protein kinase FLT3 [D835Y] |
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Ligand | BDBM397407 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Inhibition Assay |
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IC50 | <1±n/a nM |
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Citation | Naoe, T; Kiyoi, H; Hagiwara, S; Takasaki, M; Hirano, D; Nakatani, T; Yamaura, T Pharmaceutical composition for treating FLT3 mutation-positive cancer, mutant FLT3 inhibitor and uses thereof US Patent US9987278 Publication Date 6/5/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Receptor-type tyrosine-protein kinase FLT3 [D835Y] |
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Name: | Receptor-type tyrosine-protein kinase FLT3 [D835Y] |
Synonyms: | CD135 | FL cytokine receptor | FLK2 | FLT3 | FLT3(D835Y) | FLT3_HUMAN | Receptor-type tyrosine-protein kinase FLT3 (D835Y) | STK-1 | STK1 | Stem cell tyrosine kinase 1 | Tyrosine Kinase FLT3 Mutant (D835Y) |
Type: | n/a |
Mol. Mass.: | 112937.71 |
Organism: | Homo sapiens (Human) |
Description: | P36888 D835Y |
Residue: | 993 |
Sequence: | MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESP
EDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDL
QNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQD
ALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRE
CTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEM
STYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYE
IDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHA
ENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITE
GVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQD
NISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYD
LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS
ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKE
HNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDL
NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARYIMSDS
NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYK
LIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG
RVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
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BDBM397407 |
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n/a |
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Name | BDBM397407 |
Synonyms: | US9987278, Compound Reference 17 |
Type | Small organic molecule |
Emp. Form. | C25H36N8O3 |
Mol. Mass. | 496.6051 |
SMILES | CCCNc1nc(NCCc2ccncc2)ncc1C(=O)NCCC(CC)NC(=O)CNC(=O)C=C |
Structure |
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