| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-2/beta-2 |
|---|
| Ligand | BDBM50166908 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | [3H]-Epibatidine Radioligand Binding Assay |
|---|
| Ki | 0.480±n/a nM |
|---|
| Citation |  Xiao, Y; Kellar, KJ; Brown, ML; Paige, MA; Liu, Y; Levin, ED; Rezvani, AH 2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof US Patent US9993465 Publication Date 6/12/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuronal acetylcholine receptor subunit alpha-2/beta-2 |
|---|
| Name: | Neuronal acetylcholine receptor subunit alpha-2/beta-2 |
|---|
| Synonyms: | Neuronal acetylcholine receptor Alpha-2/Beta-2 | Neuronal acetylcholine receptor protein alpha-2/beta-2 subunit | Neuronal acetylcholine receptor; alpha2/beta2 | Neuronal acetylcholine recetpor; alpha2/beta2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Neuronal acetylcholine receptor subunit alpha-2 |
|---|
| Synonyms: | ACHA2_HUMAN | CHRNA2 | Neuronal acetylcholine receptor; alpha2/beta2 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 59759.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Cholinergic, Nicotinic Alpha2Beta2 0 HUMAN::Q15822 |
|---|
| Residue: | 529 |
|---|
| Sequence: | MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED
RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL
RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK
SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY
NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC
ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH
TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE
DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL
RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
|
|
|
|---|
| Component 2 |
| Name: | Neuronal acetylcholine receptor subunit beta-2 |
|---|
| Synonyms: | ACHB2_HUMAN | CHRNB2 | Neuronal acetylcholine receptor protein beta-2 subunit | Nicotinic acetylcholine receptor alpha3/beta2/alpha5 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 57020.50 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P17787 |
|---|
| Residue: | 502 |
|---|
| Sequence: | MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQL
MVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLY
NNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDR
TEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTIN
LIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKY
LMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQR
LRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPC
GCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQ
PLFQNYTTTTFLHSDHSAPSSK
|
|
|
|---|
| BDBM50166908 |
|---|
| n/a |
|---|
| Name | BDBM50166908 |
|---|
| Synonyms: | 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2(11),3,5,7,9-pentaene; dihydrochloride | CHEMBL556954 | US9993465, Varenicline | VARENICLINE |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H13N3 |
|---|
| Mol. Mass. | 211.2624 |
|---|
| SMILES | C1C2CNCC1c1cc3nccnc3cc21 |
|---|
| Structure | 
|
|---|
Search and Browse
