| Reaction Details |
|---|
 | Report a problem with these data |
| Target | A disintegrin and metalloproteinase with thrombospondin motifs 4 |
|---|
| Ligand | BDBM50337735 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Immunoblotting |
|---|
| IC50 | 0.690±n/a nM |
|---|
| Citation |  Vistnes, M; Christensen, G; Aronsen, M; Lunde, IG; Sjaastad, I; Carlson, CR Inhibitors of ADAMTS4 or ADAMTS5 for use in preventing or treating cardiac remodeling and chronic heart failure US Patent US10322143 Publication Date 6/18/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| A disintegrin and metalloproteinase with thrombospondin motifs 4 |
|---|
| Name: | A disintegrin and metalloproteinase with thrombospondin motifs 4 |
|---|
| Synonyms: | A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) | ADAMTS4 | ATS4_HUMAN | Aggrecanase-1 | KIAA0688 | Metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 90214.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75173 |
|---|
| Residue: | 837 |
|---|
| Sequence: | MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEE
IVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLG
GAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHI
LRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKR
YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLN
TPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAA
HELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGY
GHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHA
MCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGV
QFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSF
PGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHA
GCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNP
GHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQP
LTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDWLHRRAQILEILRRRPWAGRK
|
|
|
|---|
| BDBM50337735 |
|---|
| n/a |
|---|
| Name | BDBM50337735 |
|---|
| Synonyms: | CHEMBL1615187 | N-[(2S,4S)-1-({4-[2-(3,5-dimethyl-1,2-oxazol-4-yl)ethyl]piperidin-1-yl}sulfonyl)-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamide | US10322143, Compound 8m |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H34FN5O5S |
|---|
| Mol. Mass. | 511.61 |
|---|
| SMILES | C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCC(CCc2c(C)noc2C)CC1)N(O)C=O)c1ncc(F)cn1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
