| Reaction Details |
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 | Report a problem with these data |
| Target | Non-receptor tyrosine-protein kinase TYK2 [V731I] |
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| Ligand | BDBM399619 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TYK2 JH2 Domain Binding Assay |
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| Kd | 0.3±n/a nM |
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| Citation |  Greenwood, JR; Harriman, GC; Leit de Moradei, SM; Masse, CE; McLean, TH; Mondal, S TYK2 inhibitors and uses thereof US Patent US10323036 Publication Date 6/18/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Non-receptor tyrosine-protein kinase TYK2 [V731I] |
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| Name: | Non-receptor tyrosine-protein kinase TYK2 [V731I] |
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| Synonyms: | JH2 domain (V731I) | TYK2 | TYK2 (V731I) | TYK2_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 133680.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29597[V731I] |
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| Residue: | 1187 |
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| Sequence: | MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
ALSYLENKNLIHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI
HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
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| BDBM399619 |
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| n/a |
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| Name | BDBM399619 |
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| Synonyms: | US10323036, Compound I-63 | US10793574, Compound I-63 | US11220508, Compound I-63 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27N11O3 |
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| Mol. Mass. | 529.5538 |
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| SMILES | COC1CN(C1)c1cccc(Nc2cc(Nc3cccc(-c4nnn(C)n4)c3OC)c3c(n2)[nH]n(C)c3=O)n1 |
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| Structure | 
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