Reaction Details |
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Target | Sortase family protein |
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Ligand | BDBM33306 |
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Substrate/Competitor | BDBM33299 |
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Meas. Tech. | Fluorescence Resonance Energy Transfer (FRET) Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 14000±4000 nM |
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Citation | Suree, N; Yi, SW; Thieu, W; Marohn, M; Damoiseaux, R; Chan, A; Jung, ME; Clubb, RT Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors. Bioorg Med Chem17:7174-85 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Sortase family protein |
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Name: | Sortase family protein |
Synonyms: | Sortase | Sortase A (SrtA) |
Type: | Enzyme |
Mol. Mass.: | 23546.15 |
Organism: | Staphylococcus aureus |
Description: | n/a |
Residue: | 206 |
Sequence: | MKKWTNRLMTIAGVVLILVAAYLFAKPHIDNYLHDKDKDEKIEQYDKNVKEQASKDKKQQ
AKPQIPKDKSKVAGYIEIPDADIKEPVYPGPATPEQLNRGVSFAEENESLDDQNISIAGH
TFIDRPNYQFTNLKAAKKGSMVYFKVGNETRKYKMTSIRDVKPTDVGVLDEQKGKDKQLT
LITCDDYNEKTGVWEKRKIFVATEVK
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BDBM33306 |
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BDBM33299 |
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Name | BDBM33306 |
Synonyms: | rhodanine, 1-7 |
Type | Small organic molecule |
Emp. Form. | C11H7BrN2O4S2 |
Mol. Mass. | 375.218 |
SMILES | CN1C(=S)S\C(=C/c2cc(cc(Br)c2O)[N+]([O-])=O)C1=O |
Structure |
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