Reaction Details |
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Target | Sodium/bile acid cotransporter |
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Ligand | BDBM400024 |
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Substrate/Competitor | n/a |
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Meas. Tech. | HBV DNA Quantification Assay |
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EC50 | 14.9±n/a nM |
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Citation | Du, J; Kaplan, JA; Kirschberg, TA; Kobayashi, T; Lazerwith, SE; Lee, RA; Medley, JW; Mitchell, ML; Morganelli, PA; Pyun, H; Shevick, SL; Squires, NH; Watkins, WJ Substituted pyrrolizine compounds and uses thereof US Patent US10328053 Publication Date 6/25/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Sodium/bile acid cotransporter |
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Name: | Sodium/bile acid cotransporter |
Synonyms: | Bile acid transporter | NTCP | NTCP_HUMAN | SLC10A1 |
Type: | PROTEIN |
Mol. Mass.: | 38131.81 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_838517 |
Residue: | 349 |
Sequence: | MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKG
LAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSI
VMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKR
PQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVL
SALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLL
IAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA
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BDBM400024 |
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n/a |
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Name | BDBM400024 |
Synonyms: | N-(3-chloro-4-fluorophenyl)-7-(2-((3,3-difluoro-1-(methylcarbamoyl)cyclobutyl)amino)-2-oxoacetyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-5-carboxamide | US10328053, Compound 3 | US10874640, Compound 3 | US20230270719, Compound 3 |
Type | Small organic molecule |
Emp. Form. | C23H22ClF3N4O4 |
Mol. Mass. | 510.893 |
SMILES | CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2CCCc12 |
Structure |
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