| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/bile acid cotransporter |
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| Ligand | BDBM400025 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HBV DNA Quantification Assay |
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| EC50 | 63.6±n/a nM |
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| Citation |  Du, J; Kaplan, JA; Kirschberg, TA; Kobayashi, T; Lazerwith, SE; Lee, RA; Medley, JW; Mitchell, ML; Morganelli, PA; Pyun, H; Shevick, SL; Squires, NH; Watkins, WJ Substituted pyrrolizine compounds and uses thereof US Patent US10328053 Publication Date 6/25/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/bile acid cotransporter |
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| Name: | Sodium/bile acid cotransporter |
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| Synonyms: | Bile acid transporter | NTCP | NTCP_HUMAN | SLC10A1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 38131.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_838517 |
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| Residue: | 349 |
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| Sequence: | MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKG
LAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSI
VMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKR
PQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVL
SALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLL
IAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA
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| BDBM400025 |
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| n/a |
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| Name | BDBM400025 |
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| Synonyms: | (1aS,6aS)-N-(3-chloro-4-fluorophenyl)-5-(2-((3,3-difluoro-1 (methylcarbamoyl)cyclobutyl)amino)-2-oxoacetyl)-4-methyl-1,1a,6,6a-tetrahydrocyclopropa[b]pyrrolizine-3-carboxamide | US10328053, Compound 4 | US10874640, Compound 4 | US20230270719, Compound 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22ClF3N4O4 |
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| Mol. Mass. | 522.904 |
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| SMILES | CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2[C@H]3C[C@H]3Cc12 |r| |
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| Structure | 
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