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TargetE3 ubiquitin-protein ligase Mdm2
LigandBDBM35065
Substrate/Competitorp53 Peptide
Meas. Tech.Fluorescence Anisotropy Competition Binding Assay
pH7.6±n/a
Temperature296.15±n/a K
IC50>100000±n/a nM
Citation Hayashi, R; Wang, D; Hara, T; Iera, JA; Durell, SR; Appella, DH N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53. Bioorg Med Chem17:7884-93 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
E3 ubiquitin-protein ligase Mdm2
Name:E3 ubiquitin-protein ligase Mdm2
Synonyms:Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:Oncoprotein
Mol. Mass.:55196.54
Organism:Homo sapiens (Human)
Description:Q00987
Residue:491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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BDBM35065
p53 Peptide
Name:Cellular tumor antigen p53 (aa 15-29)
Synonyms:P53 | P53_TUPBE | TP53 | p53 (aa 15-29)
Type:fluorescein-conjugated peptide
Mol. Mass.:1804.95
Organism:Tupaia belangeri (Common tree shrew) (Tupaia glis belangeri)
Description:Q9TTA1 aa 15-29
Residue:15
Sequence:
SQETFSDLWKLLPEN
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