| Reaction Details |
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 | Report a problem with these data |
| Target | Protein Mdm4 |
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| Ligand | BDBM35085 |
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| Substrate/Competitor | p53 Peptide |
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| Meas. Tech. | Fluorescence Anisotropy Competition Binding Assay |
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| IC50 | >100000±n/a nM |
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| Citation |  Hayashi, R; Wang, D; Hara, T; Iera, JA; Durell, SR; Appella, DH N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53. Bioorg Med Chem17:7884-93 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Protein Mdm4 |
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| Name: | Protein Mdm4 |
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| Synonyms: | Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4 |
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| Type: | Oncoprotein |
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| Mol. Mass.: | 54842.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose. |
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| Residue: | 490 |
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| Sequence: | MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF
LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS
EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
IQLVIKVFIA
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| BDBM35085 |
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| p53 Peptide |
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| Name: | Cellular tumor antigen p53 (aa 15-29) |
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| Synonyms: | P53 | P53_TUPBE | TP53 | p53 (aa 15-29) |
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| Type: | fluorescein-conjugated peptide |
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| Mol. Mass.: | 1804.95 |
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| Organism: | Tupaia belangeri (Common tree shrew) (Tupaia glis belangeri) |
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| Description: | Q9TTA1 aa 15-29 |
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| Residue: | 15 |
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| Sequence: | |
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