| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [489-587] |
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| Ligand | BDBM820 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Protease Inhibition Assay |
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| IC50 | 0.500000±n/a nM |
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| Citation |  Munroe, JE; Shepherd, TA; Jungheim, LN; Hornback, WJ; Hatch, SD; Muesing, MA; Wiskerchen, M; Su, KS; Campanale, KM; Baxter, AJ; Colacino, JM Potent, orally bioavailable HIV-1 protease inhibitors containing noncoded D-amino acids Bioorg Med Chem Lett5:2897-902 (1995) |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Gag-Pol polyprotein [489-587] |
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| Name: | Gag-Pol polyprotein [489-587] |
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| Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10781.16 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[489-587] |
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| Residue: | 99 |
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| Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
|
|
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| BDBM820 |
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| n/a |
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| Name | BDBM820 |
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| Synonyms: | (3aR,6S,7aS)-N-tert-butyl-5-[(2R,3S)-3-[(2S)-2-acetamido-3-(naphthalene-2-sulfonyl)propanamido]-2-hydroxy-4-phenylbutyl]-octahydrothieno[3,2-c]pyridine-6-carboxamide | Saquinavir/Nelfinavir deriv. 24 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H48N4O6S2 |
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| Mol. Mass. | 708.93 |
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| SMILES | [H][C@]12CCS[C@@]1([H])C[C@H](N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CS(=O)(=O)c1ccc3ccccc3c1)NC(C)=O)C2)C(=O)NC(C)(C)C |r| |
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| Structure | 
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