Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM401810 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FLIPR Ca2+ Flux Assay |
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IC50 | 505±n/a nM |
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Citation | Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Pyrazole, triazole and tetrazole orexin receptor antagonists US Patent US10010539 Publication Date 7/3/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM401810 |
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n/a |
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Name | BDBM401810 |
Synonyms: | (2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-2-methyl-5-(4-((R)-2,2,2-trifluoro-1-hydroxyethyl)-2H-1,2,3-triazol-2-yl)piperidin-1-yl)methanone | US10010539, 27 |
Type | Small organic molecule |
Emp. Form. | C19H20F3N7O2 |
Mol. Mass. | 435.403 |
SMILES | C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)n1ncc(n1)[C@@H](O)C(F)(F)F |
Structure |
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