Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM401852 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FLIPR Ca2+ Flux Assay |
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IC50 | 6.90±n/a nM |
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Citation | Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Pyrazole, triazole and tetrazole orexin receptor antagonists US Patent US10010539 Publication Date 7/3/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R |
Type: | Protein |
Mol. Mass.: | 46817.55 |
Organism: | Rattus norvegicus (Rat) |
Description: | P56718 |
Residue: | 416 |
Sequence: | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQA
AVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFR
KLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
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BDBM401852 |
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n/a |
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Name | BDBM401852 |
Synonyms: | 2-{5-mMethyl-2-[(3R,6R)-6- methyl-1-{[2-(2,2,2- trifluoroethoxy)pyridin-3- yl]carbonyl}piperidin-3-yl]-2H- 1,2,3-triazol-4-yl}propan-2-ol | US10010539, 68 |
Type | Small organic molecule |
Emp. Form. | C20H26F3N5O3 |
Mol. Mass. | 441.4473 |
SMILES | C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1OCC(F)(F)F)n1nc(C)c(n1)C(C)(C)O |r| |
Structure |
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