| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
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| Ligand | BDBM401856 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FLIPR Ca2+ Flux Assay |
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| IC50 | 15.2±n/a nM |
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| Citation |  Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Pyrazole, triazole and tetrazole orexin receptor antagonists US Patent US10010539 Publication Date 7/3/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin/Hypocretin receptor type 1 |
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| Name: | Orexin/Hypocretin receptor type 1 |
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| Synonyms: | Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R |
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| Type: | Protein |
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| Mol. Mass.: | 46817.55 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P56718 |
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| Residue: | 416 |
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| Sequence: | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQA
AVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFR
KLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
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| BDBM401856 |
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| n/a |
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| Name | BDBM401856 |
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| Synonyms: | 2-{2-[(3R,6R)-1-{[4-Fluoro-2- (2H-1,2,3-triazol-2- yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]-5-methyl- 2H-1,2,3-triazol-4-yl}propan-2-ol | US10010539, 72 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26FN7O2 |
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| Mol. Mass. | 427.4752 |
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| SMILES | C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-n1nccn1)n1nc(C)c(n1)C(C)(C)O |r| |
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| Structure | 
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