| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
|---|
| Ligand | BDBM401891 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | FLIPR Ca2+ Flux Assay |
|---|
| IC50 | 13.8±n/a nM |
|---|
| Citation |  Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Pyrazole, triazole and tetrazole orexin receptor antagonists US Patent US10010539 Publication Date 7/3/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Orexin/Hypocretin receptor type 1 |
|---|
| Name: | Orexin/Hypocretin receptor type 1 |
|---|
| Synonyms: | Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 46817.55 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P56718 |
|---|
| Residue: | 416 |
|---|
| Sequence: | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQA
AVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFR
KLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
|
|
|
|---|
| BDBM401891 |
|---|
| n/a |
|---|
| Name | BDBM401891 |
|---|
| Synonyms: | 2-{3-Methyl-1-[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]-1H-pyrazol-4-yl}propan-2-ol (Example 107) | US10010539, 107 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H28N6O2 |
|---|
| Mol. Mass. | 408.4967 |
|---|
| SMILES | C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)n1cc(c(C)n1)C(C)(C)O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
