| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM35829 |
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| Substrate/Competitor | BDBM10852 |
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| Meas. Tech. | Radioligand Binding Assay |
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| Ki | 133±n/a nM |
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| Citation |  Gillespie, RJ; Bamford, SJ; Clay, A; Gaur, S; Haymes, T; Jackson, PS; Jordan, AM; Klenke, B; Leonardi, S; Liu, J; Mansell, HL; Ng, S; Saadi, M; Simmonite, H; Stratton, GC; Todd, RS; Williamson, DS; Yule, IA Antagonists of the human A(2A) receptor. Part 6: Further optimization of pyrimidine-4-carboxamides. Bioorg Med Chem17:6590-605 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 36520.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30542 |
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| Residue: | 326 |
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| Sequence: | MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
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| BDBM35829 |
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| BDBM10852 |
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| Name | BDBM35829 |
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| Synonyms: | pyrimidine-4-carboxamide, 111 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17N5O2 |
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| Mol. Mass. | 323.3492 |
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| SMILES | Cc1ccc(o1)-c1cc(nc(N)n1)C(=O)NCc1cccc(C)n1 |
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| Structure | 
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