Ki Summary

Reaction Details

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Target

Histamine H1 receptor

Ligand

BDBM35922

Substrate/Competitor

BDBM35938

Meas. Tech.

Radioligand Binding Assay

Temperature

298.15±n/a K

25±n/a nM

Comments

extracted

Citation

Shah, JR; Mosier, PD; Roth, BL; Kellogg, GE; Westkaemper, RB Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem17:6496-504 (2009) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Histamine H1 receptor

Name:

Histamine H1 receptor

Synonyms:

H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

55808.72

Organism:

Homo sapiens (Human)

Description:

Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.

Residue:

487

Sequence:

MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS

BDBM35922

BDBM35938

Name

BDBM35922

Synonyms:

(9,10-Dihydro-anthracen-9-ylmethyl)-dimethyl-amine | 1-(9,10-dihydroanthracen-9-yl)-N,N-dimethylmethanamine | 9,10-dihydroanthracene(DHA), 1c | CHEMBL160933

Type

Small organic molecule

Emp. Form.

C17H19N

Mol. Mass.

237.3395

SMILES

CN(C)CC1c2ccccc2Cc2ccccc12

Structure