| Reaction Details |
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 | Report a problem with these data |
| Target | Splicing factor 3B subunit 3 |
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| Ligand | BDBM36362 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | WiDr |
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| pH | 7.8±0 |
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| Temperature | 277.15±0 K |
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| EC50 | 595.0±0.0 nM |
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| Citation |  Kotake, Y; Sagane, K; Owa, T; Mimori-Kiyosue, Y; Shimizu, H; Uesugi, M; Ishihama, Y; Iwata, M; Mizui, Y Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nat Chem Biol3:570-5 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Splicing factor 3B subunit 3 |
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| Name: | Splicing factor 3B subunit 3 |
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| Synonyms: | KIAA0017 | SAP130 | SF3B3 | SF3B3_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 135544.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q15393 |
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| Residue: | 1217 |
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| Sequence: | MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFG
VIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQF
LAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENP
MFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPG
GSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFF
FLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQ
IAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDT
PQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVN
ATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPG
KKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQ
RSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSI
GFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSW
LSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFP
LQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAA
AFLNENLPESIFGAPKAGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTG
EDWYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVL
IGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQ
LIIFADDTYPRWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRG
LLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDF
FQHVEMHLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRT
PPEVSKKLEDIRTRYAF
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| BDBM36362 |
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| n/a |
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| Name | BDBM36362 |
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| Synonyms: | CID1620213 | Pladienolide analog 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C58H85F3N8O12S |
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| Mol. Mass. | 1175.402 |
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| SMILES | [H][C@@]12CS[C@H](CCCCC(=O)N(C)CCN(C)C(=O)[C@H](CCCCNC(=O)O[C@H]3\C=C\[C@H](C)[C@H](OC(=O)C[C@H](O)CC[C@@]3(C)O)C(\C)=C\C=C\[C@@H](C)C[C@H]3O[C@@H]3[C@H](C)[C@@H](O)CC)NC(=O)c3ccc(cc3)C3(N=N3)C(F)(F)F)[C@]1([H])NC(=O)N2 |c:75,t:29| |
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| Structure | 
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