| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Caspase-7 |
|---|
| Ligand | BDBM36363 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Procaspase-7 Activation Assay |
|---|
| pH | 7.4±0 |
|---|
| Temperature | 310.15±0 K |
|---|
| EC50 | 4.5e+3±n/a nM |
|---|
| Citation |  Putt, KS; Chen, GW; Pearson, JM; Sandhorst, JS; Hoagland, MS; Kwon, JT; Hwang, SK; Jin, H; Churchwell, MI; Cho, MH; Doerge, DR; Helferich, WG; Hergenrother, PJ Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol2:543-50 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Caspase-7 |
|---|
| Name: | Caspase-7 |
|---|
| Synonyms: | Apoptotic protease Mch-3 | CASP-7 | CASP7 | CASP7_HUMAN | CMH-1 | Caspase | MCH3 | caspase 7, apoptosis-related cysteine peptidase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 34273.91 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P55210 |
|---|
| Residue: | 303 |
|---|
| Sequence: | MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
FSQ
|
|
|
|---|
| BDBM36363 |
|---|
| n/a |
|---|
| Name | BDBM36363 |
|---|
| Synonyms: | CID6851947 | PAC-1 | US10166229, Example PAC-1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H28N4O2 |
|---|
| Mol. Mass. | 392.494 |
|---|
| SMILES | Oc1c(CC=C)cccc1\C=N\NC(=O)CN1CCN(Cc2ccccc2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
