| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor [Y537S] |
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| Ligand | BDBM263693 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Estrogen Receptor Coactivator Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 9.00±n/a nM |
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| Comments | extracted |
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| Citation |  Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Substituted 6,7-dihydro-5H-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof US Patent US9714221 Publication Date 7/25/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor [Y537S] |
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| Name: | Estrogen receptor [Y537S] |
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| Synonyms: | ESR | ESR1 | ESR1_HUMAN | Estrogen receptor (Y537S) | Estrogen receptor alpha Y537S | NR3A1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 66154.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03372[Y537S] |
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| Residue: | 595 |
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| Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
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| BDBM263693 |
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| n/a |
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| Name | BDBM263693 |
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| Synonyms: | 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(2- methyl-1H- indol-5-yl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol | US9714221, Example 30 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H35FN2O2 |
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| Mol. Mass. | 510.6416 |
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| SMILES | Cc1cc2cc(ccc2[nH]1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 |r,c:12| |
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| Structure | 
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