Reaction Details |
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Target | Farnesyl pyrophosphate synthase |
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Ligand | BDBM36508 |
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Substrate/Competitor | BDBM36499 |
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Meas. Tech. | Biophysical assay |
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pH | 7.4±0 |
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Temperature | 296.15±0 K |
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IC50 | 2e+3±n/a nM |
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Citation | Jahnke, W; Rondeau, JM; Cotesta, S; Marzinzik, A; Pellé, X; Geiser, M; Strauss, A; Götte, M; Bitsch, F; Hemmig, R; Henry, C; Lehmann, S; Glickman, JF; Roddy, TP; Stout, SJ; Green, JR Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. Nat Chem Biol6:660-6 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Farnesyl pyrophosphate synthase |
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Name: | Farnesyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
Type: | Enzyme |
Mol. Mass.: | 48272.89 |
Organism: | Homo sapiens (Human) |
Description: | P14324 |
Residue: | 419 |
Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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BDBM36508 |
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BDBM36499 |
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Name | BDBM36508 |
Synonyms: | 3-(Carboxymethyl)-4,7-dichloro-1H-indole-2-carboxylic acid, 9 | CID46398841 |
Type | Small organic molecules |
Emp. Form. | C11H7Cl2NO4 |
Mol. Mass. | 288.084 |
SMILES | OC(=O)Cc1c([nH]c2c(Cl)ccc(Cl)c12)C(O)=O |
Structure |
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