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TargetWee1-like protein kinase
LigandBDBM264260
Substrate/Competitorn/a
Meas. Tech.Wee-1 kinase Assay
Temperature298.15±n/a K
IC50<10±n/a nM
Commentsextracted
Citation O Dowd, CRRountree, JSBurkamp, FWilkinson, AJ Substituted pyrido[4,3-d]pyrimidines as Wee-1 inhibitors US Patent US9714244 Publication Date 7/25/2017
More Info.:Get all data from this article,  Assay Method
 
Wee1-like protein kinase
Name:Wee1-like protein kinase
Synonyms:Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN
Type:PROTEIN
Mol. Mass.:71599.12
Organism:Homo sapiens (Human)
Description:ChEMBL_1445054
Residue:646
Sequence:
MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
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  Blast E-value cutoff:
BDBM264260
n/a
NameBDBM264260
Synonyms:6-(2,6-Dichlorophenyl)-8-(3-hydroxyprop-1-yn-1-yl)-2-((3-methyl-4-(piperazin-1-yl)phenyl)amino)pyrido[4,3-d]pyrimidin-5(6H)-one | US9714244, 14
TypeSmall organic molecule
Emp. Form.C27H24Cl2N6O2
Mol. Mass.535.424
SMILESCc1cc(Nc2ncc3c(n2)c(cn(-c2c(Cl)cccc2Cl)c3=O)C#CCO)ccc1N1CCNCC1 |(-4,4.62,;-4,3.08,;-2.67,2.31,;-2.67,.77,;-1.33,,;,.77,;,2.31,;1.33,3.08,;2.67,2.31,;2.67,.77,;1.33,,;4,,;5.33,.77,;5.33,2.31,;6.67,3.08,;6.67,4.62,;5.33,5.39,;8,5.39,;9.34,4.62,;9.34,3.08,;8,2.31,;8,.77,;4,3.08,;4,4.62,;4,-1.54,;4,-3.08,;4,-4.62,;2.67,-5.39,;-4,,;-5.33,.77,;-5.33,2.31,;-6.67,3.08,;-8,2.31,;-9.34,3.08,;-9.34,4.62,;-8,5.39,;-6.67,4.62,)|
Structure
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