| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase BTK |
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| Ligand | BDBM264390 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assays |
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| IC50 | <100.0±n/a nM |
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| Citation |  Zeng, Q; Faris, M; Mollard, A; Warner, SL; Flynn, GA Multiple kinase pathway inhibitors US Patent US9714247 Publication Date 7/25/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase BTK |
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| Name: | Tyrosine-protein kinase BTK |
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| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
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| Type: | Enzyme |
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| Mol. Mass.: | 76289.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q06187 |
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| Residue: | 659 |
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| Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
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| BDBM264390 |
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| n/a |
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| Name | BDBM264390 |
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| Synonyms: | US9714247, 111 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30N6O3S |
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| Mol. Mass. | 518.631 |
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| SMILES | CCn1c2cc(Nc3ccc(CN4CCN(CC4)S(C)(=O)=O)cn3)ncc2cc(-c2ccccc2)c1=O |
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| Structure | 
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