| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM264521 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radioactive Assays of CETP-Catalyzed CE and TG Transfer (RTA Assay) |
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| IC50 | 3357±n/a nM |
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| Citation |  Ondeyka, D; Qian, X; Vachal, P; Tyagarajan, S; Smith, CJ; Li, H; Bao, J Spirocyclic CETP inhibitors US Patent US9717714 Publication Date 8/1/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM264521 |
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| n/a |
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| Name | BDBM264521 |
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| Synonyms: | 3-{3-[2-({(7R)-7-[3,5- bis(trifluoromethyl)phenyl]- 5-oxo-6-oxa-4- azaspiro[2.4]hept-4- yl}methyl)-6- (trifluoromethyl)pyridin-3- yl]-4- methoxyphenyl}propanoic acid | US9717714, 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H23F9N2O5 |
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| Mol. Mass. | 662.4996 |
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| SMILES | COc1ccc(CCC(O)=O)cc1-c1ccc(nc1CN1C(=O)O[C@H](c2cc(cc(c2)C(F)(F)F)C(F)(F)F)C11CC1)C(F)(F)F |r| |
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| Structure | 
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