| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM264522 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radioactive Assays of CETP-Catalyzed CE and TG Transfer (RTA Assay) |
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| IC50 | 68.0±n/a nM |
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| Citation |  Ondeyka, D; Qian, X; Vachal, P; Tyagarajan, S; Smith, CJ; Li, H; Bao, J Spirocyclic CETP inhibitors US Patent US9717714 Publication Date 8/1/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM264522 |
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| n/a |
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| Name | BDBM264522 |
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| Synonyms: | (8R)-8-[3,5- bis(trifluoromethyl)phenyl]-5- ({2-(3-fluoroazetidin-1-yl)-5- [4'-(hydroxymethyl)-4- methoxy-2'-methylbiphenyl-3- yl]pyrimidin-4-yl}methyl)-7- oxa-5-azaspiro[3.4]octan-6-one | US9717714, 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H33F7N4O4 |
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| Mol. Mass. | 730.6711 |
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| SMILES | COc1ccc(cc1-c1cnc(nc1CN1C(=O)O[C@H](c2cc(cc(c2)C(F)(F)F)C(F)(F)F)C11CCC1)N1CC(F)C1)-c1ccc(CO)cc1C |r| |
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| Structure | 
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