| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM264526 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radioactive Assays of CETP-Catalyzed CE and TG Transfer (RTA Assay) |
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| IC50 | 242±n/a nM |
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| Citation |  Ondeyka, D; Qian, X; Vachal, P; Tyagarajan, S; Smith, CJ; Li, H; Bao, J Spirocyclic CETP inhibitors US Patent US9717714 Publication Date 8/1/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM264526 |
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| n/a |
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| Name | BDBM264526 |
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| Synonyms: | 3'-[4-({(8R)-8-[3,5- bis(trifluoromethyl)phenyl]- 6-oxo-7-oxa-5- azaspiro[3.4]oct-5- yl}methyl)-2-morpholin-4- ylpyrimidin-5-yl]-4'- methoxy-2-methylbiphenyl- 4-carboxylic acid | US9717714, 13 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H34F6N4O6 |
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| Mol. Mass. | 756.6902 |
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| SMILES | COc1ccc(cc1-c1cnc(nc1CN1C(=O)O[C@H](c2cc(cc(c2)C(F)(F)F)C(F)(F)F)C11CCC1)N1CCOCC1)-c1ccc(cc1C)C(O)=O |r| |
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| Structure | 
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