Reaction Details |
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Target | Macrophage migration inhibitory factor |
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Ligand | BDBM50206030 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition of Tautomerase Activity of Human MIF |
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Ki | 150±n/a nM |
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Citation | Jorgensen, WL; Dziedzic, P; Cisneros, J Biaryltriazole inhibitors of macrophage migration inhibitory factor US Patent US10336721 Publication Date 7/2/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Macrophage migration inhibitory factor |
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Name: | Macrophage migration inhibitory factor |
Synonyms: | GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase |
Type: | Enzyme |
Mol. Mass.: | 12478.18 |
Organism: | Homo sapiens (Human) |
Description: | P14174 |
Residue: | 115 |
Sequence: | MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALC
SLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
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BDBM50206030 |
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n/a |
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Name | BDBM50206030 |
Synonyms: | CHEMBL3957289 | US10336721, Example 22 | US10968198, Example 22 |
Type | Small organic molecule |
Emp. Form. | C25H26FN5O4 |
Mol. Mass. | 479.5034 |
SMILES | Oc1ccc(cc1F)-n1cc(nn1)-c1ccc2cc(OCCOCCN3CCOCC3)ccc2n1 |
Structure |
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