Ki Summary

Reaction Details

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Target

Mevalonate kinase

Ligand

BDBM38524

Substrate/Competitor

n/a

Meas. Tech.

Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - MK Dose Response

IC50

>9999000±n/a nM

Citation

PubChem, PC Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - MK Dose Response PubChem Bioassay(2007)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Mevalonate kinase

Name:

Mevalonate kinase

Synonyms:

n/a

Type:

Enzyme Catalytic Domain

Mol. Mass.:

31420.64

Organism:

Streptococcus pneumoniae D39

Description:

A0A0H2ZQX9

Residue:

292

Sequence:

MTKKVGVGQAHSKIILIGEHAVVYGYPAISLPLLEVEVTCKVVPAESPWRLYEEDTLSMA
VYASLEYLNITEACIRCEIDSAIPEKRGMGSSAAISIAAIRAVFDYYQADLPHDVLEILV
NRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELEMDLSAYLVIADTGVYGHTREAIQ
VVQNKGKDALPFLHALGELTQQAEIAISQKDAEGLGQILSQAHLHLKEIGVSSLEADSLV
ETALSHGALGAKMSGGGLGGCIIALVTNLTHAQELAERLEEKGAVQTWIESL

BDBM38524

n/a

Name

BDBM38524

Synonyms:

2-[[4-(2-oxolanylmethyl)-5-[4-(1-pyrrolidinylsulfonyl)phenyl]-1,2,4-triazol-3-yl]thio]-N-propan-2-ylacetamide | 2-[[4-(oxolan-2-ylmethyl)-5-(4-pyrrolidin-1-ylsulfonylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-propan-2-yl-ethanamide | 2-[[4-(oxolan-2-ylmethyl)-5-(4-pyrrolidin-1-ylsulfonylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-propan-2-ylacetamide | MLS000035208 | N-Isopropyl-2-[5-[4-(pyrrolidine-1-sulfonyl)-phenyl]-4-(tetrahydro-furan-2-ylmethyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-acetamide | N-isopropyl-2-[[5-(4-pyrrolidinosulfonylphenyl)-4-(tetrahydrofurfuryl)-1,2,4-triazol-3-yl]thio]acetamide | SMR000005322 | cid_648872

Type

Small organic molecule

Emp. Form.

C22H31N5O4S2

Mol. Mass.

493.643

SMILES

CC(C)NC(=O)CSc1nnc(-c2ccc(cc2)S(=O)(=O)N2CCCC2)n1CC1CCCO1

Structure