Ki Summary

Reaction Details

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Target

Mevalonate kinase

Ligand

BDBM38542

Substrate/Competitor

n/a

Meas. Tech.

Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - MK Dose Response

IC50

>9999000±n/a nM

Citation

PubChem, PC Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - MK Dose Response PubChem Bioassay(2007)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Mevalonate kinase

Name:

Mevalonate kinase

Synonyms:

n/a

Type:

Enzyme Catalytic Domain

Mol. Mass.:

31420.64

Organism:

Streptococcus pneumoniae D39

Description:

A0A0H2ZQX9

Residue:

292

Sequence:

MTKKVGVGQAHSKIILIGEHAVVYGYPAISLPLLEVEVTCKVVPAESPWRLYEEDTLSMA
VYASLEYLNITEACIRCEIDSAIPEKRGMGSSAAISIAAIRAVFDYYQADLPHDVLEILV
NRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELEMDLSAYLVIADTGVYGHTREAIQ
VVQNKGKDALPFLHALGELTQQAEIAISQKDAEGLGQILSQAHLHLKEIGVSSLEADSLV
ETALSHGALGAKMSGGGLGGCIIALVTNLTHAQELAERLEEKGAVQTWIESL

BDBM38542

n/a

Name

BDBM38542

Synonyms:

(2,3-Dimethoxy-phenyl)-[4-(4-phenyl-cyclohexyl)-piperazin-1-yl]-methanone | (2,3-dimethoxyphenyl)-[4-(4-phenylcyclohexyl)-1-piperazinyl]methanone;oxalic acid | (2,3-dimethoxyphenyl)-[4-(4-phenylcyclohexyl)piperazin-1-yl]methanone;ethanedioic acid | (2,3-dimethoxyphenyl)-[4-(4-phenylcyclohexyl)piperazin-1-yl]methanone;oxalic acid | (2,3-dimethoxyphenyl)-[4-(4-phenylcyclohexyl)piperazino]methanone;oxalic acid | MLS000076513 | SMR000012888 | cid_654860

Type

Small organic molecule

Emp. Form.

C25H32N2O3

Mol. Mass.

408.5332

SMILES

COc1cccc(C(=O)N2CCN(CC2)C2CCC(CC2)c2ccccc2)c1OC |(2.16,.95,;2.16,2.49,;3.49,3.26,;4.83,2.49,;6.16,3.26,;6.16,4.8,;4.83,5.57,;4.83,7.11,;3.49,7.88,;6.16,7.88,;6.16,9.42,;7.5,10.19,;8.83,9.42,;8.83,7.88,;7.5,7.11,;10.16,10.19,;11.5,9.42,;12.83,10.19,;12.83,11.73,;11.5,12.5,;10.16,11.73,;14.16,12.5,;15.5,11.73,;16.83,12.5,;16.83,14.05,;15.5,14.82,;14.16,14.05,;3.49,4.8,;2.16,5.57,;.83,4.8,)|

Structure