Ki Summary

Reaction Details

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Target

Mevalonate kinase

Ligand

BDBM38575

Substrate/Competitor

n/a

Meas. Tech.

Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - MK Dose Response

IC50

29316±n/a nM

Citation

PubChem, PC Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - MK Dose Response PubChem Bioassay(2007)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Mevalonate kinase

Name:

Mevalonate kinase

Synonyms:

n/a

Type:

Enzyme Catalytic Domain

Mol. Mass.:

31420.64

Organism:

Streptococcus pneumoniae D39

Description:

A0A0H2ZQX9

Residue:

292

Sequence:

MTKKVGVGQAHSKIILIGEHAVVYGYPAISLPLLEVEVTCKVVPAESPWRLYEEDTLSMA
VYASLEYLNITEACIRCEIDSAIPEKRGMGSSAAISIAAIRAVFDYYQADLPHDVLEILV
NRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELEMDLSAYLVIADTGVYGHTREAIQ
VVQNKGKDALPFLHALGELTQQAEIAISQKDAEGLGQILSQAHLHLKEIGVSSLEADSLV
ETALSHGALGAKMSGGGLGGCIIALVTNLTHAQELAERLEEKGAVQTWIESL

BDBM38575

n/a

Name

BDBM38575

Synonyms:

6-oxidanylidene-3-phenyl-8-(2,4,5-trimethoxyphenyl)-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile | 6-oxo-3-phenyl-8-(2,4,5-trimethoxyphenyl)-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile | 8-asaryl-6-keto-3-phenyl-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile | MLS000080657 | SMR000035439 | cid_667069

Type

Small organic molecule

Emp. Form.

C23H23N3O4S

Mol. Mass.

437.511

SMILES

COc1cc(OC)c(cc1OC)C1CC(=O)N2CN(CSC2=C1C#N)c1ccccc1 |c:23|

Structure