Ki Summary

Reaction Details

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Target

Mevalonate kinase

Ligand

BDBM34471

Substrate/Competitor

n/a

Meas. Tech.

Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - MK Dose Response

IC50

23494.5±n/a nM

Citation

PubChem, PC Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - MK Dose Response PubChem Bioassay(2007)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Mevalonate kinase

Name:

Mevalonate kinase

Synonyms:

n/a

Type:

Enzyme Catalytic Domain

Mol. Mass.:

31420.64

Organism:

Streptococcus pneumoniae D39

Description:

A0A0H2ZQX9

Residue:

292

Sequence:

MTKKVGVGQAHSKIILIGEHAVVYGYPAISLPLLEVEVTCKVVPAESPWRLYEEDTLSMA
VYASLEYLNITEACIRCEIDSAIPEKRGMGSSAAISIAAIRAVFDYYQADLPHDVLEILV
NRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELEMDLSAYLVIADTGVYGHTREAIQ
VVQNKGKDALPFLHALGELTQQAEIAISQKDAEGLGQILSQAHLHLKEIGVSSLEADSLV
ETALSHGALGAKMSGGGLGGCIIALVTNLTHAQELAERLEEKGAVQTWIESL

BDBM34471

n/a

Name

BDBM34471

Synonyms:

4-(2,5-dimethoxyphenyl)-3-(3-hydroxyphenyl)-1H-1,2,4-triazole-5-thione | 4-(2,5-dimethoxyphenyl)-5-(3-hydroxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione | MLS000089016 | SMR000073318 | cid_892621

Type

Small organic molecule

Emp. Form.

C16H15N3O3S

Mol. Mass.

329.374

SMILES

COc1ccc(OC)c(c1)-n1c(n[nH]c1=S)-c1cccc(O)c1 |(9.75,-4.65,;9.75,-3.11,;8.41,-2.34,;7.08,-3.11,;5.75,-2.34,;5.75,-.8,;4.41,-.03,;3.08,-.8,;7.08,-.03,;8.41,-.8,;7.08,1.51,;8.33,2.41,;7.85,3.88,;6.31,3.88,;5.84,2.41,;4.37,1.94,;9.79,1.94,;10.94,2.97,;12.4,2.49,;12.72,.99,;11.58,-.04,;11.9,-1.55,;10.11,.43,)|

Structure