| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Focal adhesion kinase 1 |
|---|
| Ligand | BDBM40943 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose-response biochemical assay for inhibitors of Focal Adhesion Kinase (FAK) |
|---|
| IC50 | 12520±n/a nM |
|---|
| Citation |  PubChem, PC Dose-response biochemical assay for inhibitors of Focal Adhesion Kinase (FAK) PubChem Bioassay(2007)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Focal adhesion kinase 1 |
|---|
| Name: | Focal adhesion kinase 1 |
|---|
| Synonyms: | FADK 1 | FAK | FAK1 | FAK1_HUMAN | FLT4 | FRNK | Focal adhesion kinase (FAK) | Focal adhesion kinase (PTK2) | Focal adhesion kinase 1 (FAK) | Focal adhesion kinase 1/vascular endothelial growth factor receptor 3 | Focal adhesion kinase-related nonkinase | PPP1R71 | PTK2 | Protein phosphatase 1 regulatory subunit 71 | Protein-tyrosine kinase 2 | VHL/Focal adhesion kinase 1 | p125FAK | pp125FAK |
|---|
| Type: | Tyrosine-protein kinase |
|---|
| Mol. Mass.: | 119233.17 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q05397 |
|---|
| Residue: | 1052 |
|---|
| Sequence: | MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGD
ATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEW
KYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSY
WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESI
LKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQ
TIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFII
RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRE
RIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDH
PHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK
RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFT
SASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWA
YDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGY
PSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQE
IAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLS
RGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNE
GVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLA
LRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQM
LTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
|
|
|
|---|
| BDBM40943 |
|---|
| n/a |
|---|
| Name | BDBM40943 |
|---|
| Synonyms: | (2-Isopropyl-quinazolin-4-ylsulfanyl)-acetic acid methyl ester | 2-[(2-isopropylquinazolin-4-yl)thio]acetic acid methyl ester | 2-[(2-propan-2-yl-4-quinazolinyl)thio]acetic acid methyl ester | MLS000074241 | SMR000006837 | cid_652110 | methyl 2-(2-propan-2-ylquinazolin-4-yl)sulfanylacetate | methyl 2-(2-propan-2-ylquinazolin-4-yl)sulfanylethanoate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H16N2O2S |
|---|
| Mol. Mass. | 276.354 |
|---|
| SMILES | COC(=O)CSc1nc(nc2ccccc12)C(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
