Reaction Details |
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Target | Apoptosis regulator Bcl-2 |
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Ligand | BDBM33200 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 |
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EC50 | 4950±n/a nM |
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Citation | PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 PubChem Bioassay(2008)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Apoptosis regulator Bcl-2 |
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Name: | Apoptosis regulator Bcl-2 |
Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
Type: | Homodimer or heterodimer |
Mol. Mass.: | 26269.11 |
Organism: | Homo sapiens (Human) |
Description: | P10415 |
Residue: | 239 |
Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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BDBM33200 |
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n/a |
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Name | BDBM33200 |
Synonyms: | 2-(2-furanyl)-4-quinolinecarboxylic acid [2-(diethylamino)-2-oxoethyl] ester | 2-(2-furyl)cinchoninic acid [2-(diethylamino)-2-keto-ethyl] ester | MLS000772521 | SMR000377201 | [2-(diethylamino)-2-oxidanylidene-ethyl] 2-(furan-2-yl)quinoline-4-carboxylate | [2-(diethylamino)-2-oxoethyl] 2-(furan-2-yl)quinoline-4-carboxylate | cid_2096417 |
Type | Small organic molecule |
Emp. Form. | C20H20N2O4 |
Mol. Mass. | 352.3838 |
SMILES | CCN(CC)C(=O)COC(=O)c1cc(nc2ccccc12)-c1ccco1 |
Structure |
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