| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase Mdm2 |
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| Ligand | BDBM43398 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | E3 Ligase dose-response_384 |
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| EC50 | 10±n/a nM |
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| Citation |  PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay(2008)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| E3 ubiquitin-protein ligase Mdm2 |
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| Name: | E3 ubiquitin-protein ligase Mdm2 |
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| Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
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| Type: | Oncoprotein |
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| Mol. Mass.: | 55196.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00987 |
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| Residue: | 491 |
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| Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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| BDBM43398 |
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| n/a |
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| Name | BDBM43398 |
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| Synonyms: | (E)-4-(2-sulfanylidene-1,3-benzoxazol-3-yl)-3-buten-2-one | (E)-4-(2-sulfanylidene-1,3-benzoxazol-3-yl)but-3-en-2-one | (E)-4-(2-thioxo-1,3-benzoxazol-3-yl)but-3-en-2-one | 4-(2-Thioxo-benzooxazol-3-yl)-but-3-en-2-one | MLS000569046 | SMR000173840 | cid_5749438 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H9NO2S |
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| Mol. Mass. | 219.26 |
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| SMILES | CC(=O)C=Cn1c2ccccc2oc1=S |w:4.4| |
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| Structure | 
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